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Trans grupa (samo) podrške je osnovana 2006. godine u okviru organizacije Gayten-LGBT.
Trans grupa (samo) podrške je osnovana 2006. godine u okviru organizacije Gayten - LGBT. Možete nas kontaktirati putem e-maila: transgayten@gmail.com
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Povodom 17.maja Međunarodnog dana protiv homofobije i transfobije, organizacije za LGBT prava organizovale su akciju „Šareni piknik“ koja je bila održana na Studentskom trgu (Univerzitetski park) u petak 17.maja od 13 do 14 sati.
Tokom akcije građani su mogli da razgovaraju sa LGBT aktivistima, učestvuju u zanimljivom kvizu, deljeni su promotivni materijali i drugi prigodni pokloni.
17.maj se kao Međunarodni dan protiv homofobije i transfobije obeležava od 2004.godine kada je homoseksualnost skinuta sa liste bolesti.
Akciju organizuju: Gayten-LGBT, Izađi – grupa za podršku mladim gej muškarcima, Kvirija centar, Labris – organizacija za lezbejska ljudska prava, Siguran puls mladih, Žene u crnom.
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In most cases, ED is a result of physical causes (although it can easily be made worse by psychological factors), and can often be treated. However, silence, embarrassment, and feelings of inadequacy and humiliation only lead to further withdrawal on the part of both partners, increasing the distance and tension within the relationship. The anxiety which results can easily make a case of ED worse, leading to a vicious circle of failure and anxiety about failure.
Low self-esteem: This can be due to prior episodes of ED (thus a feeling of inadequacy) or can be the result of other issues unrelated to sexual performance.
Submitted: 23 May 2006
The recommended starting dose of tadalafil for most patients is 10 mg taken orally approximately 1 hour before sexual activity. The dose may be adjusted higher to 20 mg or lower to 5 mg depending on efficacy and tolerability. The maximum recommended dosing frequency is once per day, although for many patients tadalafil can be taken less frequently since the improvement in erectile function may last 36 hours. Tadalafil may be taken with or without food.
In the past, erection problems were thought to be "all in the man's mind." Men often were given unhelpful advice such as "don't worry" or "just relax and it will take care of itself." Today, doctors believe that when the problem is not temporary or does not go away on its own, physical factors are often the cause.
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Of 977 subjects who received double-blind medication, 774 (79.2%) completed the course of treatment. Several doses were used, but patients in all of the apomorphine dose groups reported erections firm enough for penetration more often than those taking placebo (P <.01). When separated according to dose, firm erections were reported by 45% versus 35% of the control group with the 2-mg dose. The 4-mg dose elicited positive responses in 55%, compared with 36% in the placebo group. With the 6-mg dose, 60% reported positive responses, compared with 32% in control subjects. Adverse events occurring in 10% or more of the patients in any group were nausea, sweating, dizziness, somnolence, vomiting, yawning, and asthenia. Most of these were considered mild to moderate in severity. Nausea was the most common adverse effect, which was found to be dose-related and reducible with repeated exposure to the drug.
This work has been supported by grants from the MIUR-PRIN (project no. 2005069853), Cariverona, Bando 2004 "Integrazione tra tecnologia e sviluppo di settore - Bando per progetti di ricerca a indirizzo biomedico," and the Italian Association for Cancer Research.
Agents that are injected directly into the penis exert their relaxant effect directly on the corpora cavernosal smooth muscle. They can be used as single agents or in combination. The most commonly used agents include PGE1, papaverine, and phentolamine. The dose and most effective combination of these agents must be determined for each patient. These medications can be obtained commercially as Caverject (PGE1) or can be formulated according to the physician's request by compounding pharmacies. Patients can be supplied with vials of a single agent or a combination of agents mixed in a single vial. Patients must be instructed in the proper technique for administration. A single intraurethral agent, PGE1, which has been formulated into a small suppository, is commercially available as MUSE. This agent was available prior to the introduction of sildenafil and is still used by a select group of men.
ED is treatable at any age, and awareness of this fact has been growing. More men have been seeking help and returning to normal sexual activity because of improved, successful treatments for ED. Urologists, who specialize in problems of the urinary tract, have traditionally treated ED; however, urologists accounted for only 25 percent of Viagra mentions in 1999.
Of the 99 men reviewed, the optimal dose for achieving erection satisfactory for sexual intercourse was: 25 mg 6 (6.1%), 50 mg 44 (44.4%), 75 mg 1 (1%) and 100 mg 38 (38.4%). The side effects most commonly encountered were headache (24%), flushing (16%), dyspepsia (12%), nasal congestion (10%), abnormal vision (5%), thirst (2%) and dazed feeling (2%). Uncommon side effects included palpitations (1), dizziness (1) and penile pain (1). Severe side effects necessitated withdrawal of Viagra in 2 patients (1 was a 'success' and the other a 'failure'). Out of 53 men who reported lack of side effects at Visit 2, 6 developed some side effects at Visit 3. Conversely, 11 men who had side effects at Visit 2 reported lack of them at Visit 3. There were no changes in the side effect profile between Visit 3 and Visit 4. Four men with Peyronie's disease had used sildenafil two reported success with therapy while the other two failed. There were 2 isolated reports of prolonged erection (lasting 20 30 minutes) that were painless, which did not recur. There were no serious adverse events or deaths recorded during the trial period.
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Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice variants. These unique PDEs differ in their three-dimensional structure, kinetic properties, modes of regulation, intracellular localization, cellular expression, and inhibitor sensitivities. Current data suggest that individual isozymes modulate distinct regulatory pathways in the cell. These properties therefore offer the opportunity for selectively targeting specific PDEs for treatment of specific disease states. The feasibility of these enzymes as drug targets is exemplified by the commercial and clinical successes of the erectile dysfunction drugs, sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). PDE inhibitors are also currently available or in development for treatment of a variety of other pathological conditions. In this review the basic biochemical properties, cellular regulation, expression patterns, and physiological functions of the different PDE isoforms will be discussed. How these properties relate to the current and future development of PDE inhibitors as pharmacological agents is especially considered. PDEs hold great promise as drug targets and recent research advances make this an exciting time for the field of PDE research.
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Erectile dysfunction is characterized by the inability to maintain erection. Normal erections during sleep and in the early morning suggest a psychogenic cause, while loss of these erections may signify underlying disease, often cardiovascular in origin. Other things leading to erectile dysfunction are diabetes mellitus (causing neuropathy) or hypogonadism (decreased testosterone levels due to disease affecting the testicles or the pituitary gland).
A urinalysis looking for RBCs, WBCs, protein, and glucose is also important.
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